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The series premiere introduces the hard-partying Dr. William P. Rush as he navigates his job doing discreet freelance work for society's elite after losing his job as an ER doctor. Now operating out of his vintage Mercedes, the pill popping doctor, while less than scrupulous, isn't immune to the ugliness he encounters.

Rush is called in to help an up-and-coming MMA fighter who has a past untreated medical condition that could jeopardize a fight — if not his life. Meanwhile, Alex attempts to save his job at the hospital. Later, Manny and Eve discuss their roles and boundaries in Rush’s life.

Rush is called in to treat a suspicious medical emergency at a social club where Eve is confronted by someone from her past. Meanwhile, Rush reaches out to his estranged father to help Alex get his job back. However, Rush must navigate his rocky relationship with his father all while chaperoning a troubled actor back to set after he jeopardizes his last-chance comeback.

Rush and his stepmother go to lunch, leading to an unexpected outcome. Alex’s marriage is strained because of his relationship with Rush. Rush helps a bail officer with his injured bounty, ending in a harrowing situation. Eve accepts a date trying to embrace the need for balance between her work and personal life.

In order to avoid anxiety, Rush takes on any medical call he gets; Eve discovers her value.

Rush and Alex plan a bro-weekend at a medical conference only to discover that Rush’s ex-girlfriend Sarah and her new boyfriend are also attending. Meanwhile, Rush treats a politician trying to hide his illness during an election run.

Rush treats a rock star who introduces him to, a powerful hallucinogenic drug that propels him toward a life-changing realization. Meanwhile, Alex takes a call on Rush’s behalf and gets a taste of his lifestyle. Also, Eve grows concerned when personal belongings disappear from her apartment.

Rush reconnects with his ex-girlfriend Sarah and finds her a changed person. Meanwhile, Alex goes deeper into Rush’s world and discovers that he may be in over his head. Also, Eve spends time with Manny, who encourages her to take control of her life.

Rush’s renewed relationship with Sarah gets complicated. Meanwhile, Alex tries to control the fallout with his wife. Also, Sarah urges Eve to think about the other possibilities for her future, only to have them shattered when J.P. resurfaces.